SHIP

SHIP
Lipid phosphatase containing an SH2 domain; dephosphorylates 5&’-inositol phosphate. Important in regulation of mast cell degranulation and cytokine signal transduction in lymphoid and myeloid cells generally. SHIP also modulates PI3-kinase signalling downstream of growth factor and insulin receptors. Negative signalling through SHIP appears to inhibit the ras pathway by competition with grb2 and shc for SH2 domain binding

Dictionary of molecular biology. 2004.

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